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Brava!
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Dear Dr. Seabrook, I just wanted to thank you so much for the amazing work you do. Even though all the studies are funded by drug companies, we can still do good science and get people to take notice. I am fortunate to work for a school of medicine with students who are eager to be the next authors on papers based your research. The students come to me and describe how their professors at the beginning of semester thought this would change their lives. I couldn't agree less. There have been some very positive aspects about working under a research budget; even the drug companies make us share profits with them. I appreciate it greatly! also loved having the opportunity to attend some conferences when there was a question on how to do a study on mTORC1. I will not forget all these experiences; they are truly priceless. Sincerely,
Eleanor and Luke of Texas
PS – please follow us on Facebook: https://www.facebook.com/dscourseofscience/!
UPDATE:
Here is a follow-up. This time we are targeting the same molecule for a different metabolic function: S6K, which we call AMPK/SIRT1–a little-known target in metabolic health and a new target for drug discovery:
To be sure that AMPK/SIRT1–a target I do not know much about–is a new target for development, consider this. The latest work, published in Science, shows that mice lacking AMPK/SIRT1 can live longer than their wild-type counterparts.
The generic cialis canada online pharmacy mice were bred to genetically alter Disulfiram 250 mg tablet AMPK/SIRT1 expression and/or activity–so, we had to study both the mice with normal levels of the gene and AMPK/SIRT1 knockout version. They are augmentin xr generic identical except for one thing: They have higher levels of SIRT1, which causes them to live longer.
In my opinion, the finding was profound, for its implication of how SIRT1 may enhance longevity.
Here's more from Nature News:
It might be that the mice with a "starved" form of AMP kinase (AMPK) live longer because of the beneficial effect on lipid metabolism. But they may also be protected against diabetes by the presence of SIRT1 in adipose tissue. And although no study at this stage has linked observation with longevity, Prof Shavitt said that it could help us understand more about its role in longevity general.
Another interesting aspect of this study was the use of an innovative immunoassay to measure AMPK/SIRT1 levels, and we would like to Augmentin 375mg $89.99 - $1.5 Per pill use this on our drug product, so it can be screened, to test for additional benefits…
What a wonderful set of papers! There seems to be a new emphasis on molecular targets in metabolism, and their benefits to health longevity. And in one of this series–which you will read over the next few days–the molecule AMPK–so important for metabolism, gets named a master regulator over AMP kinase: The Master Regulator of AMP Kinase in Metabolic Health and Longevity. (Read, here!) You may not even remember AMP, which was discovered over 20 years ago, has always been identified as a "master" regulator of AMP kinase… but we have been thinking about it that way. A decade and half ago, researchers noticed AMPK could act as a potent inhibitor of both AMPK isoforms–AMPK-1 and AMPK-2–that had been identified that was expressed in the nucleus.
We had also come up with a name for the enzymes that activate AMPK–a key target for aging. So we thought would rename the enzyme AMP-kinase, and we also thought naming the targets was important because otherwise the focus would be on target. When I came to work for you we found some very interesting targets for drug discovery. What we found was that the molecules activate AMPK can also target other pathways, and activate pathways like AMPK-1/AMPK-2 or other enzymes autophagy, which are linked with aging. And those pathways we thought were more relevant to aging than others, but with that strategy we're not using the targets necessarily, and we are able to have our drugs that activate different pathways, and we don't rely on activating pathways to target people, and do better results. Now we have a name. And that's how scientists talk.
(Read: Do you need mitochondria for good health? Don't panic, says new book.)
We have a new company coming on line that will target the pathways AMPK-.
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